Our Researchers
The National Pancreas Foundation (NPF) is a private, non-profit organization established to support the funding of research related to pancreatic diseases. It also provides support for the men, women, and children who are suffering from diseases of the pancreas.
 
Submitted Grant Abstracts
Heparanase gene expression and tumor metastases in pancreatic neplasms
03-01-2003 - Xiulong Xu, PhD Rush Presbyterian St. Luke’s Medical Center
Despite improvement in therapeutic strategies including surgical techniques as well as local and systemic adjuvant therapies, pancreatic cancer remains a leading cause of cancer death in industrialized countries.
Role of matrix metalloproteinase for leukocyte trafficking and alveolar capiliary leakage in pancreatitis-associated lung injury
03-01-2003 - Andrew L. Warshaw, M.D. Harvard Medical School / Massachusetts General Hospital
Acute respiratory failure is present in the majority of patients dying from acute pancreatitis. The pathophysiology is incompletely understood, and treatment is nonspecific and frequently ineffective. In experimental acute pancreatitis leukocyte-endothelial interaction may be an important factor in the pathogenesis of pulmonary injury.
Proposal of Phase II Trialof EUS guided Celiac Plexus Neurolysis of Pancreatic Cancer Pain
03-01-2003 - Michael Wallace, M.D., MPH Medical University of South Carolina
Chronic progressive pain occurs in 80-85% of patients with advanced pancreatic cancer. Despite the use of narcotics, 40-50% of patients in routine practice fail to receive adequate pain relief. Destruction of the celiac plexus with ethanol injection significantly reduces pain and narcotic use compared to placebo injection.
Do Cystic Fibrosis Gene Mutations Predispose Patients with Pancreas Divisum to Pancreatitis?
03-01-2003 - Steven D. Freedman, M.D., PhD Harvard Medical School / BI Deaconess Hospital
The aim of this study is to determine the relationship between CFTR gene dysfunction and the development of pancreatitis in patients with Pancreas Divisum by using extensive genotype and phenotype testing.
Mechanisms of Chemoresistance in Human Pancreatic Cancer
03-01-2003 - Mark P. Callery, M.D. Univeristy of Massachusetts Medical School
Apsptosis is a natural genetically determined mechanism for cell death which can regulate tumor growth in cancer. The global objective of this proposal is to enhance apoptosis and promote tumor regression in human pancreatic cancer.
 
 
 
 
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